S75 is a closed box design, M150 has bass ports. I doubt there will be a big difference in the bass frequencies.
Plus, there is more to life than woofers!
S75 is part of the 'audio' range of B&O loudspeakers, M150 belongs to the top of the line 'monitor' range. For the higher frequencies you will probably be better off with the M150's. They were the best B&O had to offer in their time, save maybe MS150's (although those are the same except for addition of a subwoofer). Also S75 are an older design.
I used to own S75. Nice sound but the M100's I use now are vastly better: the sound has more depth and realism to it, S75 were a bit flat and emotionless. This is the difference between the S and the M series!