Don't much care for Home Cinema or even 2.1, but I can say without a doubt that the Lab 5 and Penta are at least the top two in the music category for the active line, followed by the Lab 9. Some would flip-flop the latter 2 I'm sure, though another member on here once said that the Penta gets you as close as possible to the Lab 5 sound for 20,000.00 less. Having both and having severely underestimated that the Penta was any good, I'd have to agree. The MS150 passives are probably up there near the top as well.
As far as cost, between those four you pretty much have every possible cost strata covered. Pentas can be as low as a few hundred dollars if you're willing to put in some work, and Lab 5s of course are 10-15k used or 20k or so new, in US dollar terms, anyway.