I will reserve my judgement about it's design until I see it at my dealers ( I do love the navigation, from what I've seen so far, though ), but as far as the specs go, there are a couple things bothering me ( I think they've all been pointed out before, but these are the most important to me );
Mainly, the lack of a CD slot is a big minus, especially for their core customers, who don't have the time/energy/knowledge/interest/... to transfer their music from a computer, no matter how easy B&O claim it is. It should work like Olive's products: you put a CD in, it copies it in a lossless format, stores in on it's hard drive and ejects the CD ( you do need an internet connection for CD names and artwork, but from what I understand it already has that and it can be put to a better use than just software updates. The biggest problem here I think is the artwork, because as far as I can understand you can't get it with CDDB information, but I'm sure they could find a solution if they wanted - for instance like Delicious Library gets it from Amazon.
Then there is the hard drive size ( 1TB wouldn't cost much more, but I'm sure many would sleep better, knowing they have the extra space ). The other things - less important in my view: the lack of the FLAC format, it has .wav, so nothing to complain really and that 2-way remote, not a necessity, but it would be nice.