+1 on checking the tracking weight, or maybe the whole vertical tracking mechanism, if it looks like the weight is set properly.
A less-likely reason for groove jumping can be warped vinyl (or rarely, off-center hole vs. grooves). 45 RPM vs. 33RPM exacerbates the problem, as the dip (or eccentricity) whips past the cartridge faster thus the negative acceleration at the tip of the arm is greater. However, 12" 45's of heavy weight vinyl as you describe, typically being audiophile pressings, are less likely to exhibit such problems than 7" 45's of 1970s pop music or old, abused, disco/DJ pressings. (Of course any such problems are worse on the short-arm B&O turntables, where the distances are closer and an irregularity is more likely to bottom out the stylus and bang into the cartridge. There was a reason turntables that had to play 78 RPM and early 33 RPM records had tonearms that looked like this: