Note that the three driver S45 is not a true 3 way speaker, it uses the mid driver as a phase link speaker, used to fill in in a dip in response that occurs where the woofer and tweeter overlap. I think this design approach was way ahead of its time, B&O has always been good at addressing loudspeaker design issues others seem to ignore.
So, personally, I'd go with the older phase link models if it were me. But if you can listen to them your ears should guide you. Also, if memory serves the later two driver models used foam surrounds on the woofers which have likely deteriorated whereas the older models used rubber surrounds.