For videos I have no problem with DRM. I don't buy videos in the iTunes store. 😕 Allmost all my audio ist in Apple lossless format. So I stick to iTunes. PLEX integrates with iTunes for audio. It can read the iTunes library and play whats in it.
They've lifted DRM on music, not movies. And with music, it's still downloaded in a proprietary format that some programs don't read. I don't know about Plex specifically.